David Carro Vázquez
ESR13: miR-203a functions as regulator of type-2 diabetic bone disease
David obtained both his Bachelor in Biochemistry and his Master’s degree in Biotechnology from the University of Málaga, Spain, where he conducted mass spectrometry nuclear profiling of brain cancer cells In addition, he underwent placements both at the University of Ulm, Germany as well as at CNRS in Nice, France. After completing his Master project, David worked at the Charité Berlin, where his research focused on investigating the role of mesenteric fat T cells in Crohn’s disease.
Objectives: To characterize expression levels of miR-203a in different compartments of bone tissue from T2D and non-diabetic animals, and to identify novel mRNA targets under hyperglycemia compared to normal conditions. Predict and experimentally confirm the interaction of transcription factors with miR-203a promoter region, and to characterize miR-203a transcription in response to parathyroid hormone, sex hormones, and glucose. Investigate tissue expression as well as circulating levels of miR-203a together with its validated target mRNA levels in the context of onset and progression of T2D bone disease in clinical and non-clinical samples.
Host: TamiRNA GmbH, Austria
Supervisor: Dr. Matthias Hackl